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MGF exhibits local effects in skeletal muscle and without cannot travel through the body without modification. The polyethylene glycol groups protect the peptide but don’t surround it completely.Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein. This is accomplished by surrounding part of the peptide with a structure of polyethylene glycol, which can be attached to a protein molecule. MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. MGF is only stable in the blood stream for only a few minutes. It is also short acting so stability is not an issue. Biologically produced MGF is made locally and does not enter the bloodstream. Synthetic MGF is water based and when administered intramuscularly, travels into the bloodstream. PEG-MGF, or PEGylated Mechano Growth Factor is a new and innovative form of MGF that outperforms natural MGF many times over. The active sites of the peptide are still free to do their biological function. The problem with synthetic MGF is that it is introduced intramuscularly and is water based so it goes into the blood stream.PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down. This is a process required for growth of adult muscle. When used this way, MGF only remains stable in the blood stream for a few minutes. By PEGylating the MGF it is almost as efficient as local produced MGF when used intramuscularly. Natural MGF is made locally and does not travel into the bloodstream.
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